The currently released version of PhotoStructure should run fine with Big Sur under Rosetta (emulation).
I just got a new m1 Mac mini yesterday, and am adding it to PhotoStructure’s continuous integration build farm tomorrow. The PhotoStructure for Node instructions will be a bit more involved, and the Desktop edition will now have two separate installers (one for Intel Mac, and one for Apple Silicon Mac).
Update 2021-02-01: PhotoStructure on Apple Silicon should be considered experimental. A beta user just reported database corruption (which is normally extremely rare). I recently had to reformat my m1’s internal drive due to APFS corruption.
I’ll try to look into this more after v1.0.0 is out the door.