This reminded me that this suggestion to add a webdav export may address what you’re asking for, if you added, say, SHA as an exported path as well as tag paths.
I guess it matters what you mean by “manage.”
If you mean “organize”, then, at some point, I’d be delighted if PhotoStructure got this job done for most people. I expect more advanced users will already have a “workflow” that works for them that uses other software that they don’t want to give up.
If you mean “edit,” though: PhotoStructure won’t ever have the editing features of, say, Photoshop or Pixelmator. I do want to support quick edits, ala Google Photos editing sliders, but I expect people will always want to be able to edit photos in their favorite app.